视觉神经科学
在神经科学的范围内，视觉神经科学已经成为第一个涵盖从分子和细胞过程到高级生理学和视觉心理物理学的所有实验方面的真正的跨学科工作之一。在过去的半个世纪中对脊椎动物和无脊椎动物视觉系统的实验为统计信息和赋予精美特征的神经系统的设计和功能提供了一个通用框架。尽管加州大学洛杉矶分校在视觉科学的每个实验方面都有优势，但直到去年，视觉神经科学从未被用作将视觉科学家聚集在一起的组织结构。视觉神经科学亲和小组的使命是为参与者提供一个论坛，以便在生物学和心理学的各个层面进行互动，程序：这个亲密团体在十月至六月间每月开会。该计划将重点介绍亲和力小组成员实验室所产生的科学数据。将特别强调高级研究生或博士后研究人员，为他们提供正式的指导和反馈。亲和团每季度一次，将邀请来自大学以外的知名演讲者参加开放的研讨会，并与学员进行交流。
有关如何加入的信息，请联系：James Bisley博士
加州大学洛杉矶分校David Geffen医学院
电话：310-267-3
电子邮件：jbisley**[ta]**net.ucla.edu
Alapakkam P.Sampath博士
Department眼科与神经生物学
UCLA David Geffen医学院
电子邮件：asampath**[ta]**i.ucla.edu
加州大学洛杉矶分校微生物中心
认知加州大学洛杉矶分校微生物中心汇集了来自不同部门和学校的UCLA调查人员，他们对人类微生物有兴趣，代表了从口腔生物学，粘膜炎症，新陈代表谢，皮肤到脑肠相互作用等广泛的专业知识。
该中心的主要目标是为微生物感兴趣的研究者提供一个家园，促进跨学科交流。为了实现这一目标，我们计划开发技术使用（例如，生物信息学，16s分析，代表谢组学）的协调机会，为跨学科研讨会和讲座提供论坛，为学生，学员和初级教员提供发展机会微生物组领域，并确定和促进大型多学科研究项目资助机会的行动。
欲并加入，请联系该小组的教职主任
Elaine Hsaio。
ehsiao**[ta]**a.edu
加州大学洛杉矶分校微生物中心
加州大学洛杉矶分校微生物中心汇集了来自不同部门和学校的UCLA调查人员，他们对人类微生物有兴趣，代表了从口腔生物学，粘膜炎症，新陈代表谢，皮肤到脑肠相互作用等广泛的专业知识。
指导委员会
Wenyuan Shi, PhD
Professor and Chairman, Oral Biology, UCLA School of Dentistry Professor, Microbiology and Molecular Genetics, UCLA School of Medicine Founding scientist and chief science officer, C3 Jian Inc
洛杉矶 CA 9***
电话：（310***
传真：（310***
电子邮件：wenyuan**[ta]**a.edu
Aydogan Ozcan, PhD
Professor, Department of Electrical Engineering and Bioengineering, UCLA; Associate Director, California NanoSystems Institute (CNSI)
66-127D Engr.IV
电话：（310***
电子邮件：ozcan**[ta]**a.edu
网站：奥兹坎研究集团
Jonathan Jacobs, MD, PhD
Assistant Professor-in-Residence, Division of Digestive Diseases,
电话：（310***
电子邮件：JJacobs**[ta]**net.ucla.edu
网站：Jacobs实验室
Elaine Y.Hsiao, PhD
Assistant Professor, Department of Integrative Biology and Physiology, De Logi Chair in Biological Sciences, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA
电子邮件：ehsiao**[ta]**a.edu
网站：Hsiao Lab
Emeran Mayer, MD, PhD
Director,
Center for Health Science***
MC:73
洛杉矶 CA 9
电话：（310***
传真：（310***
电子邮件：emayer**[ta]**a.edu
网站：加州大学洛杉矶分校Oppenheimer中心的压力神经生物学
Jonathan Braun, MD, PhD
Chair and Professor, Pathology and Laboratory Medicine; Molecular & Medical Pharmacology, UCLA
MC: 17
电话：（310***
传真：（310***
电子邮件：jbraun**[ta]**net.ucla.edu
网站：UCLA Pathology＆Laboratory Medicine
癌症研究领域
在文献中存在2个月至11.5个月的等基因Atm缺陷小鼠寿命中巨大的不明原因的实验室间和实验室间差异。肠道微生物群在我们的健康中起着关键的作用; 部分原因是这些细菌比我们体内的人体细胞多10倍，因为它们具有巨大的代表谢能力。身体特别是免疫系统与肠道微生物之间错综复杂的相互作用强烈地明肠道微生物群影响全身稳态。肠道微生物群组成的差异与诸如肥胖症，糖尿病和行为的疾病有关。然而，正常的非致病性肠道细菌在致癌作用中的作用目前尚不清楚。
目前的研究项目
Robert Schiestl博士实验室对Atm缺陷小鼠的肠道细菌性质显着影响遗传不稳定性，寿命和淋巴瘤潜伏期进行了观察。ATM在DNA双链断裂修复，检查点控制和氧化还原平衡中非常重要。Atm - / - 小鼠模拟人类疾病共济失调毛细血管扩张症（AT），其特征是丧失运动技能，免疫系统受损，癌症风险增加和过早。AT无法治愈。他们将小鼠保持在无菌环境中，另外通过实验改变这种微生物群来特别测试肠道微生物群的贡献。他们明，同基因Atm - / - 小鼠在10％和43％之间的双基因座处有DNA缺失的显着变化，此外，Schiestl实验室从健康有益的微生物群中分离出一种细菌 - 约氏乳杆菌，其自身显着降低了基因毒性，减少了炎性细胞因子，诱导了抗炎细胞因子，并降低了自然杀伤细胞，细胞毒性T细胞和CD3细胞的流行肝脏和外周血，这些都与炎症有关。另外，他们在野生型小鼠中发现了P53缺陷型小鼠的类似差异，甚至更少。因此，这种影响是非常重要的。他们的发现提出了一个直到现在未征的实验变量，这可能具有巨大的影响。首先在AT患者中预防或延缓淋巴瘤，其次为基础研究，其中Atm和许多其他癌症倾向性小鼠模型的众多实验室间和实验室间的差异部分或全部由肠道微生物群的差异来解释。另外，我们的AT小鼠模型对肠炎症过敏。由于炎症与诸如心脏病，所有癌症，神经退行性疾病，关节炎，哮喘，糖尿病，可燃肠道疾病，克罗恩氏病等的许多疾病有关，所以在该动物模型中鉴定的细菌可以作为益生菌受益，所有这些疾病。
代表性出版物
Yamamoto，LI Maier，AT Dang，D.Berry，J.Liu，PM Ruegger，J.Yang，PA Soto，LL Presley，R.Reliene，AM Westbrook，B.Wei，A.Loy，Cr Chang，J.Braun，J.Borneman，RH Schiestl（2013）肠细菌通过炎症介导的全身性宿主氧化应激和白细胞基因毒性修饰遗传易感性小鼠中的淋巴瘤外显 - Cancer Research 73（14）：4222-4232
Westbrook，A。和RH Schiestl（2010）Atm缺陷小鼠现出对硫酸葡聚糖钠诱导的结肠炎的敏感性增加，特征在于DNA损伤升高和持续的免疫激活。Cancer Research 70,1875，
关键人物
Laurent Bentolila博士
Scientific Director, Advanced Light Microscopy/Spectroscopy Lab; Scientific Director, Macro-Scale Imaging Lab; Researcher, California NanoSystems Institute, UCLA
Advanced Light Microscopy/Spectroscopy Laboratory
California NanoSystems Institute
570
Phone: (310)***
E-mail: bento**[ta]**m.ucla.edu
Website: Laboratory
Dr.Bentolila is a senior researcher at the California NanoSystems Institute (CNSI) at the University of California, Los Angeles (UCLA).He is also the Scientific Director of the Advanced Light Microscopy/Spectroscopy Laboratory (ALMS) and the Macro-Scale Imaging Laboratory (MSI) at CNSI.Dr.Bentolila earned his B.S.in Biochemistry and M.S.in Genetics from Paris-XI University, Orsay and Ph.D.in Molecular Genetics and Immunology from the Pasteur Institute, Paris, France.He was a European Molecular Biology Organization Postdoctoral fellow at the University of California, Berkeley before joining the Department of Chemistry and Biochemistry at UCLA in
Dr.Bentolila’s long-standing research interest focuses on the application of novel fluorescent probes and advanced microscopy techniques to biology and medicine.Towards this goal, Dr.Bentolila has developed and assembled a unique collection of custom-made and commercial light microscopes for the application of novel spectroscopic methods and advanced microscopy techniques used for the study of macromolecules, cellular dynamics and nano-scale characterization of biomaterials.His most recent research projects include developing new experimental tools for visualizing and tracking cells, bacteria and parasites within a host.
Dr.Bentolila is the recipient of several awards from the Burroughs Wellcome Fund, the European Molecular Biology Organization and the Roux Foundation.
Relevant Recent Publications
Bentolila LA, Prakash R, Mihic-Probst D, Wadehra M, Kleinman HK, Carmichael TS, Péault B, Barnhill RL and Lugassy C.Imaging of Angiotropism/Vascular Co-Option in a Murine Model of Brain Melanoma.Implications for Melanoma Progression along Extravascular Pathways.2016.Scientific Reports.In press
Chen AL, Kim EW, Toh JY, Vashisht AA, Rashoff AQ, Van C, Huang AS, Moon AS, Bell HN, Bentolila LA, Wohlschlegel JA and Bradley PJ.Novel components of the Toxoplasma inner membrane complex revealed by BioID.2015.mBio 6(1) e0***
Kisalu NK, Langousis GD, Bentolila LA, Ralston KS, Hill KL.Mouse infection and pathogenesis by Trypanosoma brucei motility mutants.Cellular Microbiology.2014.16(6)***
Mitchell-Jordan S，Chen H，Franklin S，Stefani E，Bentolila LA和Vondriska TM。超分辨率STED显微镜显示内源性心肌细胞染色质的特征。J Mol Cell Cardiol。53（4）：552-8
Dino Di Carlo博士
Dino Di Carlo, PhD
Professor, Department of Bioengineering; Member, California NanoSystems Institute, Jonsson Comprehensive Cancer Center
5121E Engineering V
电话：（310***
电子邮件：dicarlo**[ta]**a.edu
Di Carlo实验室
Dino Di Carlo is a Professor in the Department of Bioengineering at UCLA.Over the last 8 years he pioneered using inertial fluid dynamic effects for the control, separation, and analysis of cells in microfluidic devices.His work now extends into numerous fields of biomedicine and biotechnology including directed cellular evolution of microbes, cell and microbial analysis for rapid diagnostics, new amplified molecular assays, next generation biomaterials, and phenotypic drug screening.He also serves as Director of the Cancer Nanotechnology Program of the Jonsson Comprehensive Cancer Center at UCLA and holds a visiting Professorship at the University of Tokyo.He co-founded and currently advises four companies that are commercializing intellectual property developed in his lab over the last six years (CytoVale, Vortex Biosciences, Tempo Therapeutics, and Ferrologix).He has received numerous honors and awards including the Pioneers of Miniaturization Prize in 2015, Analytical Chemistry Young Innovator Award in 2014, the National Science Foundation (NSF) CAREER award, the U.S.Office of Naval Research (ONR) Young Investigator Award, the Packard Fellowship, the Defense Advanced Research Projects Agency (DARPA) Young Faculty Award, the National Institutes of Health (NIH) Director’s New Innovator Award and the Coulter Translational Research Awa***
出版物：Weaver WM，Milisavljevic V，Miller JF，Di Carlo D.，“Fluid flow induces biofilm formation in Staphylococcus epidermidis polysaccharide intracellular adhesin-positive clinical isolates，”Appl Environ Microbiol。2012年8月; 78（16）：5890-6。doi：10.1128 / AEM.01139-12。Epub 2012年6月15日。
Weaver WM，Dharmaraja S，Milisavljevic V，Di Carlo D.，“剪切应力对皮葡萄球菌和人血浆纤维蛋白原分子受体 - 配体相互作用的影响，使用分子案微流体，”Lab Chip。
Aydogan Ozcan，博士
Phone: (310)***
E-mail: ozcan**[ta]**a.edu
Website: The Ozcan Research Group
Dr.Ozcan is the Chancellor’s Professor at UCLA and an HHMI Professor with the Howard Hughes Medical Institute, leading the Bio- and Nano-Photonics Laboratory at UCLA School of Engineering and is also the Associate Director of the California NanoSystems Institute (CNSI).Dr.Ozcan holds 32 issued patents (all of which are licensed) and20 pending patent applications and is also the author of one book and the co-author of more than 400 peer reviewed research articles in major scientific journals and conferences.Dr.Ozcan is a Fellow of SPIE and OSA, and has received major awards including the Presidential Early Career Award for Scientists and Engineers (PECASE), International Commission for Optics (ICO) Prize, SPIE Biophotonics Technology Innovator Award, SPIE Early Career Achievement Award, ARO Young Investigator Award, NSF CAREER Award, NIH Director’s New Innovator Award, ONR Young Investigator Award, IEEE Photonics Society Young Investigator Award and MIT’s TR35 Award for his seminal contributions to near-field and on-chip imaging, and telemedicine based diagnostics.Dr.Ozcan is also the recipient of the National Geographic Emerging Explorer Award, National Academy of Engineering (NAE) The Grainger Foundation Frontiers of Engineering Award, Popular Science Brilliant 10 Award, Gates Foundation Grand Challenges Award, Popular Mechanics Breakthrough Award, Netexplorateur Award, Microscopy Today Innovation Award, and the Wireless Innovation Award organized by the Vodafone Americas Foundation as well as the Okawa Foundation Awa***
出版物：A.Greenbaum，Y.Zhang，A.Feizi，P.Chung，W.Luo，SR Kandukuri，and A.Ozcan，“Wide-field Computational Imaging of Pathology Slides using Lensfree On-Chip Microscopy”，Science Translational Medicine （AAAS）（***
DOI：10.1126 / scitranslmed***
Q.Wei，W.Luo，S.Chiang，T.Kappel，C.Mejia，D.Tseng，R.Chan，E.Yan，H.Qi，F.Shabbir，H.Ozkan，S.Feng and A Ozcan，“移动
电话上单个DNA分子的成像和大小”，ACS Nano（***
DOI：10.1021 / nn505821y
A.Greenbaum，W.Luo，TW。Su，Z.G r cs，L.Xue，SO Isikman，AF Coskun，O.Mudanyali和A.Ozcan，“
在宽场片上显微镜的成就和仍然存在的挑战”，Nature Methods（2012）DOI ：10.1038 / nmeth
Robert Schiestl博士
Robert Schiestl, PhD
Professor, Departments of Pathology and Laboratory Medicine, Environmental Health Sciences, Radiation Oncology, Jonsson Comprehensive Cancer Center, UCLA
心血管疾病研究领域
动脉粥样硬化与冠心病
由于胆固醇，氧化脂质，白细胞，细胞废物和钙在动脉壁内积聚的结果，斑块的积聚导致动脉粥样硬化和导致冠心病的大中型动脉的狭窄和心肌梗塞。动脉壁代表谢，脂蛋白，免疫系统和凝血因子在动脉粥样硬化，动脉狭窄和最终闭塞中起主要作用。遗传和环境因素影响不同个体动脉粥样硬化的发生率。此外，肠道微生物群现在已经与各种动脉粥样硬化危险因素有关，包括血脂，胆汁酸，胰岛素抵抗和炎症。最近，通过微生物群的作用得到的代表谢物三甲胺-N-氧化物显示与动脉粥样硬化密切相关。参与的实验室（Jake Lusis，Mohamad Navab，Alan Fogelman）主要对小鼠模型中宿主 - 微生物相互作用的机制研究感兴趣。我们还在芬兰的一个横断面人群中进行了大量肠道微生物的流行病学研究。
我们已经观察到，许多抑制炎症的肽通过在肠的水平上起作用，我们正在探索它们的作用部分是由肠道微生物群的作用所介导的可能性。我们观察到，在LDL受体无效小鼠中饲喂含有促炎性脂质的饮食后，P.Pacteriode和P.Verruccomrobrobia的比例改变，我们的抗炎肽逆转了这种改变。
Navab M，Hough G，Buga GM，Su F，Wagner AC，Meriwether D，Chattopadhyay A，Gao F，Grijalva V，Danciger JS，Van Lenten BJ，Org E，Lusis AJ，Pan C，Anantharamaiah GM，Farias-Eisner R，Smyth SS，Reddy ST，Fogelman AM。转基因
Navab M，Chattopadhyay A，Hough G，Meriwether D，Fogelman SI，Wagner AC，Grijalva V，Su F，Anantharamaiah GM，Hwang LH，Faull KF，Reddy ST，Fogelman AM。肠源性溶血磷脂酸在血脂异常和动脉粥样硬化中的来源和作用。J Lipid Res。2015年4月; 56（4）：871-87。PMCID：PMC4373744。
Jake Lusis, PhD
Professor, Departments of Medicine, Cardiology, Human Genetics, Microbiology, Immunology & Molecular Genetics, UCLA
UCLA Med-Cardio/Microbio
3730 MRL
BOX 95
Los Angeles CA 9***
Phone: (310)***
E-mail: jlusis**[ta]**net.ucla.edu
Website: Lusis Laboratory
My PhD is in biophysics but somehow I ended up doing mouse genetics for my postdoc.I’m still doing mouse genetics, now with a focus on complex genetic traits, particularly those related to cardiovascular and metabolic disorders.With the development of high throughput technologies, such as expression arrays and sequencing, we have found it useful to marry such data with genetic analysis (‘systems genetics’).I also enjoy teaching.
Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SL.(2011) Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.Nature.472:57-63.PMCID:PM***
Bennett BJ, Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen S, Lusis AJ.(2013) Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.Cell Metab.17:49-60.PMCID:PM***
Elin Org，Brian W.Parks，Jong Wha J Joo，Benjamin Emert，William Schwartzman，Eun Yong Kang，Margarete Mehrabian，Calvin Pan，Rob Knight，Robert Gunsalus，Thomas A.Drake，Eleazar Eskin和Aldons J.Lusis。（2015）宿主 - 肠道微生物群相互作用的遗传和环境控制。Genome Res。
研究领域认知与心理健康
在美国，将近五分之一的人患有精神疾病，但许多精神疾病的根本原因大部分是未知的，缺乏有效的治疗方法。最近的临床前研究揭示了微生物操作对复杂的高阶行为（包括焦虑，社交性，认知和情绪行为）的显着影响。而且，分子评估揭示了微生物组在调节神经化学代表谢，全脑基因达，小胶质细胞激活和血脑屏障通透性中的关键作用。在这些发现的推动下，最近对患有精神障碍（包括精神分裂症和抑郁症）的患者的检查揭示了微生物群的生态失调。总之，这些发现提出了微生物组的变化是否有助于，博士的实验室伊莱恩萧在加州大学洛杉矶分校正在研究肠道微生物与神经系统之间的神经发育障碍和分子信号传导的症状的微生物 - 肠 - 脑效应。萧博士此前在这方面的工作明，产后修改共栖菌群可改善自闭症遗传和环境危险因素的小鼠模型中的GI和行为症状。这项工作是首次证明微生物调节定型，感觉运动和交流行为，并进一步揭示微生物介导的神经活性代表谢物水平的变化影响行为。Hsiao实验室进行的一项独立研究发现，人和小鼠微生物群中的一个特定的细菌聚生体可逆地调节宿主5-羟色胺的生物合成并改善小鼠中5-羟色胺相关疾病的型。
（Yano JM），Yu K，Donaldson G，Shastri G，Ma L，Ann P，Nagler C，Ismagilov RF，Mazmanian SK，Hsiao EY（2015）肠道微生物中的土着细菌调节宿主5-羟色胺的生物合成。Cell，161：26***
（2）微生物调节与神经发育相关的行为和生理异常障碍。Cell，155：1451-***
Hsiao EY，McBride SW，Chow J，Mazmanian SK，Patterson PH（2012）在小鼠中建立自闭症风险因子导致永久性免疫失调。PNAS 109：***
Elaine Y.Hsiao博士
Dr.Elaine Y.Hsiao is an Assistant Professor in the Department of Integrative Biology & Physiology at UCLA, where she leads a laboratory studying fundamental interactions between the microbiome, brain and behavior, and their applications to neurological disorders.Her studies on the relationships between the microbiota, immune system and nervous system led her to discover that the microbiota can regulate behavioral, metabolic and gastrointestinal abnormalities relevant to autism spectrum disorder (ASD).Her work in this area, and on neuroimmune interactions in autism, has led to several honors, including the National Institutes of Health Director’s Early Independence Award, distinction as Forbes’ 30 Under
医学博士Helen Lavretsky
Helen Lavretsky, MD
Professor in Residence, Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA
研究领域结缔组织疾病
涉及结缔组织的自身免疫病症具有复杂的发病起因和不同的临床现。全身性硬化症或硬皮病）是所有结缔组织疾病中死亡率最高的原因，大多数系统性硬化症患者患有严重的胃肠道症状。虽然系统性硬化症的胃肠道功能障碍的原因尚不清楚，但是加州大学洛杉矶分校的风湿病专家Elizabeth Volkmann博士最近与病理学和检验医学系主任Jonathan Braun博士合作，发现系统性硬化症患者的肠道微生物群是否有改变。
加州大学洛杉矶分校的胃肠病专家团队（包括Bennett Roth博士，Terri Getzug博士和Jeffrey Conklin博士，UCLA硬皮病微生物组织倡议组织）也试确定某些微生物物种是否有助于系统性硬化症的胃肠型。Volkmann博士的研究小组最近证明，与健康对照组相比，系统性硬化症患者病原微生物（侵入性，促炎性）增加，共生菌（正常，健康）减少。此外，该研究组发现，脆弱类杆菌（一种共生细菌种类）水平较低的系统性硬化症患者，与该种类较高的患者相比，有较严重的胃肠道症状。
Jonathan Braun博士
Dr.Jonathan Braun is Professor and Chair of Pathology and Laboratory Medicine, and Professor of Molecular and Medical Pharmacology at the David Geffen School of Medicine, and Chair of Pathology and Laboratory Medicine.A distinguished pathologist and mucosal immunologist , his 30 year career has been devoted to mucosal host-microbial interaction and the immune cell biology of chronic inflammatory disease (IBD and HIV) and lymphoma pathogenesis.With a long-standing commitment to inflammatory bowel disease, in recent years he has focused on the relationship of the intestinal microbiome and function to human genetic disease variation in IBD disease pathogenesis, penetrance, and phenotype.He has innovated in the detection and bioinformatics analysis of microbiome, metabolites, and peptides, through participation in the NIDDK IBD Genetics Consortium and NIH HMP2 projects, and as PI of the CCFA Microbiome Initiative.
Tong M, McHardy I, Ruegger P, Goudarzi M, Kashyap PC, Haritunians T, Li X, Graeber TG, Schwager E, Huttenhower C, Fornace AJ Jr, Sonnenburg JL, McGovern DP, Borneman J, Braun J.Reprograming of gut microbiome energy metabolism by the FUT2 Crohn’s disease risk polymorphism.ISME J.2014 Nov;8(11):2193-206.doi: 10.1038/ismej.2014.64.PMID: ***
McHardy IH, Goudarzi M, Tong M, Ruegger PM, Schwager E, Weger JR, Graeber TG, Sonnenburg JL, Horvath S, Huttenhower C, McGovern DP, Fornace AJ Jr, Borneman J, Braun J.Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships.Microbiome.2013 Jun 5;1(1):17.doi: 10.1186/2049-
McHardy IH, Li X, Tong M, Ruegger P, Jacobs J, Borneman J, Anton P, Braun J.HIV Infection is associated with compositional and functional shifts in the rectal mucosal microbiota.Microbiome.2013 Oct 12;1(1):26.doi: 10.1186/2049-
Active Funding in Microbiome-Related Research
Funding Agency/Grant Number: NIH U54 DK10
Title: “Characterizing the gut microbial community for diagnosis and therapy of IBD”
Goals: To identify the relationship of microbial composition, microbial genes, and their metabolite and peptide products in the intestinal mucosa of IBD patients
Funding Agency/Grant Number: CCFA Microbiome Consortium/323814 Crohn’s and Colitis Foundation of America
Title: “Establishing Mechanistically Validated Targets and Lead Molecules for Microbiome-based Therapy in IBD”
Goals: 机械地验证确定IBD疾病状态和活性的候选微生物群及其产品; 确定针对这些经过验证的候选人的主要分子; 并通过纵向多元分析来扩展潜在的候选人。
Elizabeth Volkmann，MD，MS
Elizabeth Volkmann, MD, MS
Clinical Instructor, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at UCLA
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